SPKB

Signal Peptide Knowledge Base

General Information


SPKB ID  SPKB00860

Signal sequence   MLNKLFIAILIVITAVIG

Length  18

Organism  Komagataella phaffii

UniProt ID  C4R442,

Motif  1..18



Activity Information


Pathway  SRP-dependent

Natural/Artificial  Natural

Subcellular location  ER

Secretion efficiency  NA

Type  Sec/SPI



Structure Information


PDB ID  NA,

Predicted Structure ID  SPKB00860.cif

Structure  SPKB00860.cif
Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)
Loading PAE…
Expected Position Error (Ångströms)


Physicochemical Information


Molecular weight  1942.51734

Aliphatic index  216.6666667

Isoelectric point  9.700002532

Charge (pH=7)   0.997689266

Topological polar surface area  647.36

Aromaticity  0.055555556

Average rotatable bonds  3.611111111

Number of hydrogen bond donors  22

Number of hydrogen bond acceptors  23

X logP energy  0.3729

Hydropathy 



Literature Information


Title  SIGNAL PEPTIDES FOR INCREASED PROTEIN SECRETION

DOI  NA,

Publication Year  2024

PubMed ID  NA,

Patent ID  US20240141363A1,



Faculty of Applied Sciences, Macao Polytechnic University, Macao, China.