SPKB

Signal Peptide Knowledge Base

General Information


SPKB ID  SPKB00744

Signal sequence   MWQLLLPTALLLLVSAGMRT

Length  20

Organism  Homo sapiens (Human)

UniProt ID  A0A8V8TQ03,

Motif  1..20



Activity Information


Pathway  SRP-dependent

Natural/Artificial  Natural

Subcellular location  ER

Secretion efficiency  NA

Type  Sec/SPI



Structure Information


PDB ID  5D6D,

Predicted Structure ID  SPKB00744.cif

Structure  SPKB00744.cif
Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)
Loading PAE…
Expected Position Error (Ångströms)


Physicochemical Information


Molecular weight  2227.79484

Aliphatic index  161

Isoelectric point  10.55000222

Charge (pH=7)   0.997980988

Topological polar surface area  788.9

Aromaticity  0.05

Average rotatable bonds  3.55

Number of hydrogen bond donors  28

Number of hydrogen bond acceptors  28

X logP energy  -2.72153

Hydropathy 



Literature Information


Title  Heterologous intron within a signal peptide

DOI  NA,

Publication Year  2016

PubMed ID  NA,

Patent ID  US9249201B2,



Faculty of Applied Sciences, Macao Polytechnic University, Macao, China.