SPKB

Signal Peptide Knowledge Base

General Information


SPKB ID  SPKB00743

Signal sequence   MGVRHPPCSHRLLAVCALVSLATA

Length  24

Organism  Homo sapiens (Human)

UniProt ID  P10253,

Motif  1..24



Activity Information


Pathway  SRP-dependent

Natural/Artificial  Natural

Subcellular location  ER

Secretion efficiency  NA

Type  Sec/SPI



Structure Information


PDB ID  NA,

Predicted Structure ID  SPKB00743.cif

Structure  SPKB00743.cif
Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)
Loading PAE…
Expected Position Error (Ångströms)


Physicochemical Information


Molecular weight  2503.04004

Aliphatic index  117.9166667

Isoelectric point  8.840856441

Charge (pH=7)   2.055846427

Topological polar surface area  956.89

Aromaticity  0

Average rotatable bonds  3.166666667

Number of hydrogen bond donors  36

Number of hydrogen bond acceptors  35

X logP energy  -9.13926

Hydropathy 



Literature Information


Title  Heterologous intron within a signal peptide

DOI  NA,

Publication Year  2016

PubMed ID  NA,

Patent ID  US9249201B2,



Faculty of Applied Sciences, Macao Polytechnic University, Macao, China.