SPKB

Signal Peptide Knowledge Base

General Information


SPKB ID  SPKB00731

Signal sequence   MRWSWIFLLLLSITSANA

Length  18

Organism  Artificial

UniProt ID  NA,

Motif  1..18



Activity Information


Pathway  SRP-dependent

Natural/Artificial  Artificial

Subcellular location  ER

Secretion efficiency  Increase R593 antibody production by 1.8 times

Type  Sec/SPI



Structure Information


PDB ID  NA,

Predicted Structure ID  SPKB00731.cif

Structure  SPKB00731.cif
Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)
Loading PAE…
Expected Position Error (Ångströms)


Physicochemical Information


Molecular weight  2122.55584

Aliphatic index  141.1111111

Isoelectric point  10.55000222

Charge (pH=7)   0.997980988

Topological polar surface area  775.51

Aromaticity  0.166666667

Average rotatable bonds  3.666666667

Number of hydrogen bond donors  29

Number of hydrogen bond acceptors  26

X logP energy  -3.10353

Hydropathy 



Literature Information


Title  Signal peptide, and use thereof for producing recombinant proteins

DOI  NA,

Publication Year  2014

PubMed ID  NA,

Patent ID  US8883450B2,



Faculty of Applied Sciences, Macao Polytechnic University, Macao, China.