SPKB

Signal Peptide Knowledge Base

General Information


SPKB ID  SPKB00706

Signal sequence   MYQRMLRCGAELGLPGGGGGGGGGGGAGGRLALLWIVPLTLSGLLGVAWGASSLGAHHIH

Length  60

Organism  Homo sapiens (Human)

UniProt ID  NA,

Motif  1..60



Activity Information


Pathway  SRP-dependent

Natural/Artificial  Natural

Subcellular location  ER

Secretion efficiency  NA

Type  Sec/SPI



Structure Information


PDB ID  NA,

Predicted Structure ID  SPKB00706.cif

Structure  SPKB00706.cif
Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)
Loading PAE…
Expected Position Error (Ångströms)


Physicochemical Information


Molecular weight  5792.74304

Aliphatic index  104.1666667

Isoelectric point  9.502456718

Charge (pH=7)   2.209651631

Topological polar surface area  2247.5

Aromaticity  0.05

Average rotatable bonds  3.1

Number of hydrogen bond donors  81

Number of hydrogen bond acceptors  77

X logP energy  -22.95129

Hydropathy 



Literature Information


Title  High frequency of neurexin 1BETA signal peptide structural variants in patients with autism

DOI  NA,

Publication Year  2011

PubMed ID  NA,

Patent ID  US7871820B2,



Faculty of Applied Sciences, Macao Polytechnic University, Macao, China.