SPKB

Signal Peptide Knowledge Base

General Information


SPKB ID  SPKB00705

Signal sequence   MYQRMLRCGAELGSPGGGGGGGGGGGAGGRLALLWIVPLTLSGLLGVAWGASSLGAHHIH

Length  60

Organism  Homo sapiens (Human)

UniProt ID  P58400,

Motif  1..60



Activity Information


Pathway  SRP-dependent

Natural/Artificial  Natural

Subcellular location  ER

Secretion efficiency  NA

Type  Sec/SPI



Structure Information


PDB ID  NA,

Predicted Structure ID  SPKB00705.cif

Structure  SPKB00705.cif
Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)
Loading PAE…
Expected Position Error (Ångströms)


Physicochemical Information


Molecular weight  5766.66184

Aliphatic index  97.66666667

Isoelectric point  9.502456718

Charge (pH=7)   2.209651631

Topological polar surface area  2267.73

Aromaticity  0.05

Average rotatable bonds  3.083333333

Number of hydrogen bond donors  82

Number of hydrogen bond acceptors  78

X logP energy  -25.00509

Hydropathy 



Literature Information


Title  High frequency of neurexin 1BETA signal peptide structural variants in patients with autism

DOI  NA,

Publication Year  2011

PubMed ID  NA,

Patent ID  US7871820B2,



Faculty of Applied Sciences, Macao Polytechnic University, Macao, China.