SPKB

Signal Peptide Knowledge Base

General Information


SPKB ID  SPKB00703

Signal sequence   MQFKNVALAASVAALSATASAEGYTPGEPWSTLTPTGSISCGAAEYTTTFGIAVQAITSSKAKR

Length  64

Organism  Artificial

UniProt ID  NA,

Motif  1..64



Activity Information


Pathway  SRP-dependent

Natural/Artificial  Artificial

Subcellular location  ER

Secretion efficiency  NA

Type  Sec/SPI



Structure Information


PDB ID  NA,

Predicted Structure ID  SPKB00703.cif

Structure  SPKB00703.cif
Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)
Loading PAE…
Expected Position Error (Ångströms)


Physicochemical Information


Molecular weight  6441.24624

Aliphatic index  70.46875

Isoelectric point  8.494854971

Charge (pH=7)   0.93874571

Topological polar surface area  2651.54

Aromaticity  0.078125

Average rotatable bonds  3.171875

Number of hydrogen bond donors  95

Number of hydrogen bond acceptors  96

X logP energy  -35.07483

Hydropathy 



Literature Information


Title  Pichia pastoris PIR1 secretion signal peptide for recombinant protein expression and Pichia pastoris PIR1 and PIR2 anchor domain peptides for recombinant surface display

DOI  NA,

Publication Year  2010

PubMed ID  NA,

Patent ID  US7741075B2,



Faculty of Applied Sciences, Macao Polytechnic University, Macao, China.