SPKB

Signal Peptide Knowledge Base

General Information


SPKB ID  SPKB00701

Signal sequence   MQYKKTLVASALAATTLAAYAPSEPWSTLTPTATYSGGVTDYASTFGIAVQPISTTSSASSAATTASSKAKR

Length  72

Organism  Artificial

UniProt ID  NA,

Motif  1..72



Activity Information


Pathway  SRP-dependent

Natural/Artificial  Artificial

Subcellular location  ER

Secretion efficiency  NA

Type  Sec/SPI



Structure Information


PDB ID  NA,

Predicted Structure ID  SPKB00701.cif

Structure  SPKB00701.cif
Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)
Loading PAE…
Expected Position Error (Ångströms)


Physicochemical Information


Molecular weight  7266.11444

Aliphatic index  65.41666667

Isoelectric point  9.915638282

Charge (pH=7)   2.995620803

Topological polar surface area  3023.48

Aromaticity  0.083333333

Average rotatable bonds  3.125

Number of hydrogen bond donors  110

Number of hydrogen bond acceptors  112

X logP energy  -42.69803

Hydropathy 



Literature Information


Title  Pichia pastoris PIR1 secretion signal peptide for recombinant protein expression and Pichia pastoris PIR1 and PIR2 anchor domain peptides for recombinant surface display

DOI  NA,

Publication Year  2010

PubMed ID  NA,

Patent ID  US7741075B2,



Faculty of Applied Sciences, Macao Polytechnic University, Macao, China.