SPKB

Signal Peptide Knowledge Base

General Information


SPKB ID  SPKB00700

Signal sequence   MQYKKSLVASALVATSLAAYAPKDPWSTLTPSATYKGGITDYSSTFGIAVEPIATTASSKAKR

Length  63

Organism  Artificial

UniProt ID  NA,

Motif  1..63



Activity Information


Pathway  SRP-dependent

Natural/Artificial  Artificial

Subcellular location  ER

Secretion efficiency  NA

Type  Sec/SPI



Structure Information


PDB ID  NA,

Predicted Structure ID  SPKB00700.cif

Structure  SPKB00700.cif
Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)
Loading PAE…
Expected Position Error (Ångströms)


Physicochemical Information


Molecular weight  6571.50464

Aliphatic index  74.6031746

Isoelectric point  10.10665829

Charge (pH=7)   3.995477219

Topological polar surface area  2645.99

Aromaticity  0.095238095

Average rotatable bonds  3.301587302

Number of hydrogen bond donors  95

Number of hydrogen bond acceptors  97

X logP energy  -30.50843

Hydropathy 



Literature Information


Title  Pichia pastoris PIR1 secretion signal peptide for recombinant protein expression and Pichia pastoris PIR1 and PIR2 anchor domain peptides for recombinant surface display

DOI  NA,

Publication Year  2010

PubMed ID  NA,

Patent ID  US7741075B2,



Faculty of Applied Sciences, Macao Polytechnic University, Macao, China.