SPKB

Signal Peptide Knowledge Base

General Information


SPKB ID  SPKB00699

Signal sequence   MKLAALSTIALTILPVALAGYAPPDDWSTLTAKGVYPGAFSSYSNTFGIIVEPLTSSVILTPATTTHVV

Length  69

Organism  Artificial

UniProt ID  NA,

Motif  1..69



Activity Information


Pathway  SRP-dependent

Natural/Artificial  Artificial

Subcellular location  ER

Secretion efficiency  NA

Type  Sec/SPI



Structure Information


PDB ID  NA,

Predicted Structure ID  SPKB00699.cif

Structure  SPKB00699.cif
Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)
Loading PAE…
Expected Position Error (Ångströms)


Physicochemical Information


Molecular weight  7123.27124

Aliphatic index  111.7391304

Isoelectric point  5.519156

Charge (pH=7)   -0.911579829

Topological polar surface area  2645.48

Aromaticity  0.086956522

Average rotatable bonds  3.101449275

Number of hydrogen bond donors  92

Number of hydrogen bond acceptors  98

X logP energy  -23.8832

Hydropathy 



Literature Information


Title  Pichia pastoris PIR1 secretion signal peptide for recombinant protein expression and Pichia pastoris PIR1 and PIR2 anchor domain peptides for recombinant surface display

DOI  NA,

Publication Year  2010

PubMed ID  NA,

Patent ID  US7741075B2,



Faculty of Applied Sciences, Macao Polytechnic University, Macao, China.