SPKB

Signal Peptide Knowledge Base

General Information


SPKB ID  SPKB00496

Signal sequence   MLGNKRPGLSGLTLALSLLVCLGALAEA

Length  28

Organism  Homo sapiens (Human)

UniProt ID  NA,

Motif  1..28



Activity Information


Pathway  SRP-dependent

Natural/Artificial  Artificial

Subcellular location  ER

Secretion efficiency  NA

Type  Sec/SPI



Structure Information


PDB ID  NA,

Predicted Structure ID  SPKB00496.cif

Structure  SPKB00496.cif
Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)
Loading PAE…
Expected Position Error (Ångströms)


Physicochemical Information


Molecular weight  2782.39574

Aliphatic index  150

Isoelectric point  8.545125282

Charge (pH=7)   0.937486361

Topological polar surface area  1069.23

Aromaticity  0

Average rotatable bonds  3.321428571

Number of hydrogen bond donors  38

Number of hydrogen bond acceptors  38

X logP energy  -9.14903

Hydropathy 



Literature Information


Title  DNA molecule encoding a mutant prepro-neuropeptide Y, a mutant signal peptide, and uses thereof

DOI  NA,

Publication Year  2000

PubMed ID  NA,

Patent ID  US6046317A,



Faculty of Applied Sciences, Macao Polytechnic University, Macao, China.