SPKB

Signal Peptide Knowledge Base

General Information


SPKB ID  SPKB00484

Signal sequence   MKVLLRLICFIALLISS

Length  17

Organism  Homo sapiens (Human)

UniProt ID  P14778,

Motif  1..17



Activity Information


Pathway  SRP-dependent

Natural/Artificial  Natural

Subcellular location  ER

Secretion efficiency  NA

Type  Sec/SPI



Structure Information


PDB ID  NA,

Predicted Structure ID  SPKB00484.cif

Structure  SPKB00484.cif
Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)
Loading PAE…
Expected Position Error (Ångströms)


Physicochemical Information


Molecular weight  1933.52784

Aliphatic index  206.4705882

Isoelectric point  9.833242293

Charge (pH=7)   1.935711238

Topological polar surface area  657.3

Aromaticity  0.058823529

Average rotatable bonds  3.882352941

Number of hydrogen bond donors  25

Number of hydrogen bond acceptors  24

X logP energy  -0.49773

Hydropathy 



Literature Information


Title  Expression system comprising mutant yeast strain and expression vector encoding synthetic signal peptide

DOI  NA,

Publication Year  1996

PubMed ID  NA,

Patent ID  US5538863A,



Faculty of Applied Sciences, Macao Polytechnic University, Macao, China.