SPKB

Signal Peptide Knowledge Base

General Information


SPKB ID  SPKB00477

Signal sequence   MKYTSYILAFQLCIVLGSLG

Length  20

Organism  Homo sapiens (Human)

UniProt ID  NA,

Motif  1..20



Activity Information


Pathway  SRP-dependent

Natural/Artificial  Natural

Subcellular location  ER

Secretion efficiency  NA

Type  Sec/SPI



Structure Information


PDB ID  NA,

Predicted Structure ID  SPKB00477.cif

Structure  SPKB00477.cif
Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)
Loading PAE…
Expected Position Error (Ångströms)


Physicochemical Information


Molecular weight  2220.71314

Aliphatic index  136.5

Isoelectric point  8.50263122

Charge (pH=7)   0.934013721

Topological polar surface area  786.48

Aromaticity  0.15

Average rotatable bonds  3.6

Number of hydrogen bond donors  29

Number of hydrogen bond acceptors  30

X logP energy  -3.5931

Hydropathy 



Literature Information


Title  Human Y-interferon signal peptide-tumor necrosis factor(TNF) gene fusions

DOI  NA,

Publication Year  1994

PubMed ID  NA,

Patent ID  US5324655A,



Faculty of Applied Sciences, Macao Polytechnic University, Macao, China.