SPKB

Signal Peptide Knowledge Base

General Information


SPKB ID  SPKB00475

Signal sequence   MAPSGKSTLLLLFLLLCLPSWNAGA

Length  25

Organism  Artificial

UniProt ID  NA,

Motif  1..25



Activity Information


Pathway  NA

Natural/Artificial  Artificial

Subcellular location  Periplasmic space

Secretion efficiency  Hirudin Variant: 5-10mg/L

Type  NA



Structure Information


PDB ID  NA,

Predicted Structure ID  SPKB00475.cif

Structure  SPKB00475.cif
Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)
Loading PAE…
Expected Position Error (Ångströms)


Physicochemical Information


Molecular weight  2617.20284

Aliphatic index  136.8

Isoelectric point  8.545189979

Charge (pH=7)   0.93571455

Topological polar surface area  909.96

Aromaticity  0.08

Average rotatable bonds  3.24

Number of hydrogen bond donors  32

Number of hydrogen bond acceptors  34

X logP energy  -5.2511

Hydropathy 



Literature Information


Title  Signal peptide, DNA sequences coding for the latter, expression vectors carrying one of these sequences, gram-negative bacteria transformed by these vectors, and process for the periplasmic production of a polypeptide

DOI  NA,

Publication Year  1994

PubMed ID  NA,

Patent ID  US5284768A,



Faculty of Applied Sciences, Macao Polytechnic University, Macao, China.