SPKB

Signal Peptide Knowledge Base

General Information


SPKB ID  SPKB00458

Signal sequence   MKLWFSTLKLKKAAAVLLFSCVALAGCANNQTNA

Length  34

Organism  Bacillus licheniformis

UniProt ID  NA,

Motif  1..34



Activity Information


Pathway  Sec

Natural/Artificial  Natural

Subcellular location  Extracellular environment

Secretion efficiency  Human growth hormone: 340ng/OD600

Type  Sec/SPII



Structure Information


PDB ID  1W7F,

Predicted Structure ID  SPKB00458.cif

Structure  SPKB00458.cif
Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)
Loading PAE…
Expected Position Error (Ångströms)


Physicochemical Information


Molecular weight  3627.38204

Aliphatic index  106.4705882

Isoelectric point  10.34881288

Charge (pH=7)   3.872854732

Topological polar surface area  1396.77

Aromaticity  0.088235294

Average rotatable bonds  3.558823529

Number of hydrogen bond donors  50

Number of hydrogen bond acceptors  50

X logP energy  -12.268

Hydropathy 



Literature Information


Title  Modified signal peptides

DOI  NA,

Publication Year  1987

PubMed ID  NA,

Patent ID  US4711844A,



Faculty of Applied Sciences, Macao Polytechnic University, Macao, China.