SPKB

Signal Peptide Knowledge Base

General Information


SPKB ID  SPKB00455

Signal sequence   MRAWIFFLLCLAGRALA

Length  17

Organism  Artificial

UniProt ID  NA,

Motif  1..17



Activity Information


Pathway  SRP-dependent

Natural/Artificial  Artificial

Subcellular location  ER

Secretion efficiency  NA

Type  Sec/SPI



Structure Information


PDB ID  9KAS,

Predicted Structure ID  SPKB00455.cif

Structure  SPKB00455.cif
Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)
Loading PAE…
Expected Position Error (Ångströms)


Physicochemical Information


Molecular weight  1952.45214

Aliphatic index  138.2352941

Isoelectric point  10.52640717

Charge (pH=7)   1.936002961

Topological polar surface area  668.51

Aromaticity  0.176470588

Average rotatable bonds  3.588235294

Number of hydrogen bond donors  26

Number of hydrogen bond acceptors  22

X logP energy  -0.48456

Hydropathy 



Literature Information


Title  Signal peptide mRNA for improving expression level of secretory protein and mRNA engineering method and application thereof

DOI  NA,

Publication Year  2024

PubMed ID  NA,

Patent ID  CN119040362A,



Faculty of Applied Sciences, Macao Polytechnic University, Macao, China.