SPKB

Signal Peptide Knowledge Base

General Information


SPKB ID  SPKB00453

Signal sequence   MARPLCTLLLLMATLAGALA

Length  20

Organism  Artificial

UniProt ID  NA,

Motif  1..20



Activity Information


Pathway  SRP-dependent

Natural/Artificial  Artificial

Subcellular location  ER

Secretion efficiency  NA

Type  Sec/SPI



Structure Information


PDB ID  NA,

Predicted Structure ID  SPKB00453.cif

Structure  SPKB00453.cif
Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)
Loading PAE…
Expected Position Error (Ångströms)


Physicochemical Information


Molecular weight  2043.61534

Aliphatic index  161.5

Isoelectric point  8.549912035

Charge (pH=7)   0.936006272

Topological polar surface area  709.79

Aromaticity  0

Average rotatable bonds  3.25

Number of hydrogen bond donors  26

Number of hydrogen bond acceptors  27

X logP energy  -3.36983

Hydropathy 



Literature Information


Title  Signal peptide mRNA for improving expression level of secretory protein and mRNA engineering method and application thereof

DOI  NA,

Publication Year  2024

PubMed ID  NA,

Patent ID  CN119040362A,



Faculty of Applied Sciences, Macao Polytechnic University, Macao, China.