SPKB

Signal Peptide Knowledge Base

General Information


SPKB ID  SPKB00452

Signal sequence   MNLLLILTFVAAAVA

Length  15

Organism  Artificial

UniProt ID  NA,

Motif  1..15



Activity Information


Pathway  SRP-dependent

Natural/Artificial  Artificial

Subcellular location  ER

Secretion efficiency  NA

Type  Sec/SPI



Structure Information


PDB ID  NA,

Predicted Structure ID  SPKB00452.cif

Structure  SPKB00452.cif
Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)
Loading PAE…
Expected Position Error (Ångströms)


Physicochemical Information


Molecular weight  1559.97074

Aliphatic index  195.3333333

Isoelectric point  6.099999998

Charge (pH=7)   -0.002015701

Topological polar surface area  534.04

Aromaticity  0.066666667

Average rotatable bonds  3.266666667

Number of hydrogen bond donors  18

Number of hydrogen bond acceptors  19

X logP energy  -0.9404

Hydropathy 



Literature Information


Title  Signal peptide mRNA for improving expression level of secretory protein and mRNA engineering method and application thereof

DOI  NA,

Publication Year  2024

PubMed ID  NA,

Patent ID  CN119040362A,



Faculty of Applied Sciences, Macao Polytechnic University, Macao, China.