SPKB

Signal Peptide Knowledge Base

General Information


SPKB ID  SPKB00451

Signal sequence   MAFLWLLSCWALLGTTFG

Length  18

Organism  Artificial

UniProt ID  NA,

Motif  1..18



Activity Information


Pathway  SRP-dependent

Natural/Artificial  Artificial

Subcellular location  ER

Secretion efficiency  NA

Type  Sec/SPI



Structure Information


PDB ID  NA,

Predicted Structure ID  SPKB00451.cif

Structure  SPKB00451.cif
Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)
Loading PAE…
Expected Position Error (Ångströms)


Physicochemical Information


Molecular weight  2030.47304

Aliphatic index  119.4444444

Isoelectric point  5.922539791

Charge (pH=7)   -0.063990417

Topological polar surface area  650.29

Aromaticity  0.222222222

Average rotatable bonds  3.333333333

Number of hydrogen bond donors  25

Number of hydrogen bond acceptors  24

X logP energy  -0.4568

Hydropathy 



Literature Information


Title  Signal peptide mRNA for improving expression level of secretory protein and mRNA engineering method and application thereof

DOI  NA,

Publication Year  2024

PubMed ID  NA,

Patent ID  CN119040362A,



Faculty of Applied Sciences, Macao Polytechnic University, Macao, China.