SPKB

Signal Peptide Knowledge Base

General Information


SPKB ID  SPKB00450

Signal sequence   MALWMRLLPLLALLALWGPDPAAA

Length  24

Organism  Artificial

UniProt ID  NA,

Motif  1..24



Activity Information


Pathway  SRP-dependent

Natural/Artificial  Artificial

Subcellular location  ER

Secretion efficiency  NA

Type  Sec/SPI



Structure Information


PDB ID  6B3Q,

Predicted Structure ID  SPKB00450.cif

Structure  SPKB00450.cif
Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)
Loading PAE…
Expected Position Error (Ångströms)


Physicochemical Information


Molecular weight  2604.25294

Aliphatic index  155

Isoelectric point  6.338718596

Charge (pH=7)   -0.001572528

Topological polar surface area  837.03

Aromaticity  0.083333333

Average rotatable bonds  3.166666667

Number of hydrogen bond donors  28

Number of hydrogen bond acceptors  29

X logP energy  0.87907

Hydropathy 



Literature Information


Title  Signal peptide mRNA for improving expression level of secretory protein and mRNA engineering method and application thereof

DOI  NA,

Publication Year  2024

PubMed ID  NA,

Patent ID  CN119040362A,



Faculty of Applied Sciences, Macao Polytechnic University, Macao, China.