SPKB

Signal Peptide Knowledge Base

General Information


SPKB ID  SPKB00449

Signal sequence   MKWVTFISLLFLFSSSSRA

Length  19

Organism  Artificial

UniProt ID  NA,

Motif  1..19



Activity Information


Pathway  SRP-dependent

Natural/Artificial  Artificial

Subcellular location  ER

Secretion efficiency  NA

Type  Sec/SPI



Structure Information


PDB ID  NA,

Predicted Structure ID  SPKB00449.cif

Structure  SPKB00449.cif
Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)
Loading PAE…
Expected Position Error (Ångströms)


Physicochemical Information


Molecular weight  2220.65754

Aliphatic index  102.6315789

Isoelectric point  11.65177567

Charge (pH=7)   1.997685954

Topological polar surface area  812.21

Aromaticity  0.210526316

Average rotatable bonds  3.736842105

Number of hydrogen bond donors  31

Number of hydrogen bond acceptors  29

X logP energy  -5.07523

Hydropathy 



Literature Information


Title  Signal peptide mRNA for improving expression level of secretory protein and mRNA engineering method and application thereof

DOI  NA,

Publication Year  2024

PubMed ID  NA,

Patent ID  CN119040362A,



Faculty of Applied Sciences, Macao Polytechnic University, Macao, China.