SPKB

Signal Peptide Knowledge Base

General Information


SPKB ID  SPKB00447

Signal sequence   MALPVTALLLPLALLLHAARP

Length  21

Organism  Artificial

UniProt ID  NA,

Motif  1..21



Activity Information


Pathway  SRP-dependent

Natural/Artificial  Artificial

Subcellular location  ER

Secretion efficiency  NA

Type  Sec/SPI



Structure Information


PDB ID  8EK5,

Predicted Structure ID  SPKB00447.cif

Structure  SPKB00447.cif
Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)
Loading PAE…
Expected Position Error (Ångströms)


Physicochemical Information


Molecular weight  2194.79344

Aliphatic index  186.1904762

Isoelectric point  10.5517587

Charge (pH=7)   1.088890079

Topological polar surface area  729.76

Aromaticity  0

Average rotatable bonds  3.095238095

Number of hydrogen bond donors  24

Number of hydrogen bond acceptors  26

X logP energy  -0.89983

Hydropathy 



Literature Information


Title  Signal peptide mRNA for improving expression level of secretory protein and mRNA engineering method and application thereof

DOI  NA,

Publication Year  2024

PubMed ID  NA,

Patent ID  CN119040362A,



Faculty of Applied Sciences, Macao Polytechnic University, Macao, China.