SPKB

Signal Peptide Knowledge Base

General Information


SPKB ID  SPKB00446

Signal sequence   MNSFSTSAFGPVAFSLGLLLVLPAAFPAP

Length  29

Organism  Artificial

UniProt ID  NA,

Motif  1..29



Activity Information


Pathway  SRP-dependent

Natural/Artificial  Artificial

Subcellular location  ER

Secretion efficiency  NA

Type  Sec/SPI



Structure Information


PDB ID  8QY5,

Predicted Structure ID  SPKB00446.cif

Structure  SPKB00446.cif
Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)
Loading PAE…
Expected Position Error (Ångströms)


Physicochemical Information


Molecular weight  2923.46274

Aliphatic index  104.4827586

Isoelectric point  6.099999998

Charge (pH=7)   -0.002015701

Topological polar surface area  987.2

Aromaticity  0.137931034

Average rotatable bonds  2.862068966

Number of hydrogen bond donors  32

Number of hydrogen bond acceptors  37

X logP energy  -7.1484

Hydropathy 



Literature Information


Title  Signal peptide mRNA for improving expression level of secretory protein and mRNA engineering method and application thereof

DOI  NA,

Publication Year  2024

PubMed ID  NA,

Patent ID  CN119040362A,



Faculty of Applied Sciences, Macao Polytechnic University, Macao, China.