SPKB

Signal Peptide Knowledge Base

General Information


SPKB ID  SPKB00445

Signal sequence   MRRMQLLLLIALSLALVTNS

Length  20

Organism  Artificial

UniProt ID  NA,

Motif  1..20



Activity Information


Pathway  SRP-dependent

Natural/Artificial  Artificial

Subcellular location  ER

Secretion efficiency  NA

Type  Sec/SPI



Structure Information


PDB ID  NA,

Predicted Structure ID  SPKB00445.cif

Structure  SPKB00445.cif
Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)
Loading PAE…
Expected Position Error (Ångströms)


Physicochemical Information


Molecular weight  2256.83684

Aliphatic index  180.5

Isoelectric point  12.50010931

Charge (pH=7)   1.997977677

Topological polar surface area  886.89

Aromaticity  0

Average rotatable bonds  3.9

Number of hydrogen bond donors  32

Number of hydrogen bond acceptors  30

X logP energy  -5.78686

Hydropathy 



Literature Information


Title  Signal peptide mRNA for improving expression level of secretory protein and mRNA engineering method and application thereof

DOI  NA,

Publication Year  2024

PubMed ID  NA,

Patent ID  CN119040362A,



Faculty of Applied Sciences, Macao Polytechnic University, Macao, China.