SPKB

Signal Peptide Knowledge Base

General Information


SPKB ID  SPKB00443

Signal sequence   MDAMKRGLCCVLLLCGAVFVSP

Length  22

Organism  Artificial

UniProt ID  NA,

Motif  1..22



Activity Information


Pathway  SRP-dependent

Natural/Artificial  Artificial

Subcellular location  ER

Secretion efficiency  NA

Type  Sec/SPI



Structure Information


PDB ID  5VN3,

Predicted Structure ID  SPKB00443.cif

Structure  SPKB00443.cif
Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)
Loading PAE…
Expected Position Error (Ångströms)


Physicochemical Information


Molecular weight  2326.93534

Aliphatic index  119.5454545

Isoelectric point  8.045811842

Charge (pH=7)   0.812208291

Topological polar surface area  811.08

Aromaticity  0.045454545

Average rotatable bonds  3.409090909

Number of hydrogen bond donors  31

Number of hydrogen bond acceptors  32

X logP energy  -5.06213

Hydropathy 



Literature Information


Title  Signal peptide mRNA for improving expression level of secretory protein and mRNA engineering method and application thereof

DOI  NA,

Publication Year  2024

PubMed ID  NA,

Patent ID  CN119040362A,



Faculty of Applied Sciences, Macao Polytechnic University, Macao, China.