SPKB

Signal Peptide Knowledge Base

General Information


SPKB ID  SPKB00442

Signal sequence   MEFGLSWVFLVALFRGVQC

Length  19

Organism  Artificial

UniProt ID  NA,

Motif  1..19



Activity Information


Pathway  SRP-dependent

Natural/Artificial  Artificial

Subcellular location  ER

Secretion efficiency  NA

Type  Sec/SPI



Structure Information


PDB ID  NA,

Predicted Structure ID  SPKB00442.cif

Structure  SPKB00442.cif
Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)
Loading PAE…
Expected Position Error (Ångströms)


Physicochemical Information


Molecular weight  2202.66014

Aliphatic index  112.6315789

Isoelectric point  6.232433001

Charge (pH=7)   -0.062218605

Topological polar surface area  765.43

Aromaticity  0.210526316

Average rotatable bonds  3.631578947

Number of hydrogen bond donors  28

Number of hydrogen bond acceptors  26

X logP energy  -1.96543

Hydropathy 



Literature Information


Title  Signal peptide mRNA for improving expression level of secretory protein and mRNA engineering method and application thereof

DOI  NA,

Publication Year  2024

PubMed ID  NA,

Patent ID  CN119040362A,



Faculty of Applied Sciences, Macao Polytechnic University, Macao, China.