SPKB

Signal Peptide Knowledge Base

General Information


SPKB ID  SPKB00441

Signal sequence   MDMRVPAQLLGLLLLWLSGARC

Length  22

Organism  Artificial

UniProt ID  NA,

Motif  1..22



Activity Information


Pathway  SRP-dependent

Natural/Artificial  Artificial

Subcellular location  ER

Secretion efficiency  NA

Type  Sec/SPI



Structure Information


PDB ID  8JBV,

Predicted Structure ID  SPKB00441.cif

Structure  SPKB00441.cif
Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)
Loading PAE…
Expected Position Error (Ångströms)


Physicochemical Information


Molecular weight  2457.05144

Aliphatic index  146.3636364

Isoelectric point  8.54983383

Charge (pH=7)   0.936449445

Topological polar surface area  905.84

Aromaticity  0.045454545

Average rotatable bonds  3.636363636

Number of hydrogen bond donors  33

Number of hydrogen bond acceptors  31

X logP energy  -4.21436

Hydropathy 



Literature Information


Title  Signal peptide mRNA for improving expression level of secretory protein and mRNA engineering method and application thereof

DOI  NA,

Publication Year  2024

PubMed ID  NA,

Patent ID  CN119040362A,



Faculty of Applied Sciences, Macao Polytechnic University, Macao, China.