SPKB

Signal Peptide Knowledge Base

General Information


SPKB ID  SPKB00440

Signal sequence   MGWSCIILFLVATATGVHS

Length  19

Organism  Artificial

UniProt ID  NA,

Motif  1..19



Activity Information


Pathway  SRP-dependent

Natural/Artificial  Artificial

Subcellular location  ER

Secretion efficiency  NA

Type  Sec/SPI



Structure Information


PDB ID  5M5E,

Predicted Structure ID  SPKB00440.cif

Structure  SPKB00440.cif
Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)
Loading PAE…
Expected Position Error (Ångströms)


Physicochemical Information


Molecular weight  2006.40834

Aliphatic index  123.1578947

Isoelectric point  7.35902981

Charge (pH=7)   0.026918674

Topological polar surface area  712.51

Aromaticity  0.105263158

Average rotatable bonds  3.210526316

Number of hydrogen bond donors  27

Number of hydrogen bond acceptors  27

X logP energy  -4.7147

Hydropathy 



Literature Information


Title  Signal peptide mRNA for improving expression level of secretory protein and mRNA engineering method and application thereof

DOI  NA,

Publication Year  2024

PubMed ID  NA,

Patent ID  CN119040362A,



Faculty of Applied Sciences, Macao Polytechnic University, Macao, China.