SPKB

Signal Peptide Knowledge Base

General Information


SPKB ID  SPKB00439

Signal sequence   METDTLLLWVLLLWVPGSTGAA

Length  22

Organism  Artificial

UniProt ID  NA,

Motif  1..22



Activity Information


Pathway  SRP-dependent

Natural/Artificial  Artificial

Subcellular location  ER

Secretion efficiency  NA

Type  Sec/SPI



Structure Information


PDB ID  4KUC,

Predicted Structure ID  SPKB00439.cif

Structure  SPKB00439.cif
Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)
Loading PAE…
Expected Position Error (Ångströms)


Physicochemical Information


Molecular weight  2386.83154

Aliphatic index  141.8181818

Isoelectric point  3.550073557

Charge (pH=7)   -1.999794094

Topological polar surface area  852.73

Aromaticity  0.090909091

Average rotatable bonds  3.272727273

Number of hydrogen bond donors  30

Number of hydrogen bond acceptors  30

X logP energy  -3.3482

Hydropathy 



Literature Information


Title  Signal peptide mRNA for improving expression level of secretory protein and mRNA engineering method and application thereof

DOI  NA,

Publication Year  2024

PubMed ID  NA,

Patent ID  CN119040362A,



Faculty of Applied Sciences, Macao Polytechnic University, Macao, China.