SPKB

Signal Peptide Knowledge Base

General Information


SPKB ID  SPKB00437

Signal sequence   MWWRLWWLLLLLLLLWPMVWAAA

Length  23

Organism  Artificial

UniProt ID  NA,

Motif  1..23



Activity Information


Pathway  SRP-dependent

Natural/Artificial  Artificial

Subcellular location  ER

Secretion efficiency  NA

Type  Sec/SPI



Structure Information


PDB ID  NA,

Predicted Structure ID  SPKB00437.cif

Structure  SPKB00437.cif
Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)
Loading PAE…
Expected Position Error (Ångströms)


Physicochemical Information


Molecular weight  2981.78744

Aliphatic index  178.2608696

Isoelectric point  10.55000222

Charge (pH=7)   0.997980988

Topological polar surface area  851.37

Aromaticity  0.260869565

Average rotatable bonds  3.695652174

Number of hydrogen bond donors  32

Number of hydrogen bond acceptors  27

X logP energy  9.81417

Hydropathy 



Literature Information


Title  Signal peptide mRNA for improving expression level of secretory protein and mRNA engineering method and application thereof

DOI  NA,

Publication Year  2024

PubMed ID  NA,

Patent ID  CN119040362A,



Faculty of Applied Sciences, Macao Polytechnic University, Macao, China.