SPKB

Signal Peptide Knowledge Base

General Information


SPKB ID  SPKB00436

Signal sequence   MWWRLWWLLLLLLLLWPMVWA

Length  21

Organism  Artificial

UniProt ID  NA,

Motif  1..21



Activity Information


Pathway  SRP-dependent

Natural/Artificial  Artificial

Subcellular location  ER

Secretion efficiency  NA

Type  Sec/SPI



Structure Information


PDB ID  NA,

Predicted Structure ID  SPKB00436.cif

Structure  SPKB00436.cif
Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)
Loading PAE…
Expected Position Error (Ångströms)


Physicochemical Information


Molecular weight  2839.62984

Aliphatic index  185.7142857

Isoelectric point  10.55000222

Charge (pH=7)   0.997980988

Topological polar surface area  793.17

Aromaticity  0.285714286

Average rotatable bonds  3.857142857

Number of hydrogen bond donors  30

Number of hydrogen bond acceptors  25

X logP energy  10.80477

Hydropathy 



Literature Information


Title  Signal peptide mRNA for improving expression level of secretory protein and mRNA engineering method and application thereof

DOI  NA,

Publication Year  2024

PubMed ID  NA,

Patent ID  CN119040362A,



Faculty of Applied Sciences, Macao Polytechnic University, Macao, China.