SPKB

Signal Peptide Knowledge Base

General Information


SPKB ID  SPKB00428

Signal sequence   MRQVWFSWIVGLFLCFFNVSSAALGLCLA

Length  29

Organism  Artificial

UniProt ID  NA,

Motif  1..29



Activity Information


Pathway  SRP-dependent

Natural/Artificial  Artificial

Subcellular location  ER

Secretion efficiency  Lactoferrin: 0.75mg/L

Type  Sec/SPI



Structure Information


PDB ID  6C26,

Predicted Structure ID  SPKB00428.cif

Structure  SPKB00428.cif
Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)
Loading PAE…
Expected Position Error (Ångströms)


Physicochemical Information


Molecular weight  3279.96924

Aliphatic index  121.0344828

Isoelectric point  8.231408964

Charge (pH=7)   0.874031556

Topological polar surface area  1118.47

Aromaticity  0.206896552

Average rotatable bonds  3.482758621

Number of hydrogen bond donors  42

Number of hydrogen bond acceptors  39

X logP energy  -4.04763

Hydropathy 



Literature Information


Title  Fusion signal peptide and application thereof in fermentation production of lactoferrin by using kluyveromyces marxianus

DOI  NA,

Publication Year  2024

PubMed ID  NA,

Patent ID  CN118978605A,



Faculty of Applied Sciences, Macao Polytechnic University, Macao, China.