SPKB

Signal Peptide Knowledge Base

General Information


SPKB ID  SPKB00427

Signal sequence   MRQVWFSWIVGLFLCFFNVSSAGALGLCLA

Length  30

Organism  Artificial

UniProt ID  NA,

Motif  1..30



Activity Information


Pathway  SRP-dependent

Natural/Artificial  Artificial

Subcellular location  ER

Secretion efficiency  Lactoferrin: 0.51mg/L

Type  Sec/SPI



Structure Information


PDB ID  6C26,

Predicted Structure ID  SPKB00427.cif

Structure  SPKB00427.cif
Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)
Loading PAE…
Expected Position Error (Ångströms)


Physicochemical Information


Molecular weight  3337.02114

Aliphatic index  117

Isoelectric point  8.231408964

Charge (pH=7)   0.874031556

Topological polar surface area  1147.57

Aromaticity  0.2

Average rotatable bonds  3.433333333

Number of hydrogen bond donors  43

Number of hydrogen bond acceptors  40

X logP energy  -4.93143

Hydropathy 



Literature Information


Title  Fusion signal peptide and application thereof in fermentation production of lactoferrin by using kluyveromyces marxianus

DOI  NA,

Publication Year  2024

PubMed ID  NA,

Patent ID  CN118978605A,



Faculty of Applied Sciences, Macao Polytechnic University, Macao, China.