SPKB

Signal Peptide Knowledge Base

General Information


SPKB ID  SPKB00420

Signal sequence   MRRKRVAAALALVAGAAVAVTGNAPAQA

Length  28

Organism  Streptomyces lividans TK24

UniProt ID  NA,

Motif  1..28



Activity Information


Pathway  Sec

Natural/Artificial  Artificial

Subcellular location  Extracellular environment

Secretion efficiency  NA

Type  Sec/SPI



Structure Information


PDB ID  NA,

Predicted Structure ID  SPKB00420.cif

Structure  SPKB00420.cif
Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)
Loading PAE…
Expected Position Error (Ångströms)


Physicochemical Information


Molecular weight  2705.22054

Aliphatic index  108.571428571429

Isoelectric point  12.8074277946726

Charge (pH=7)   3.99767933163999

Topological polar surface area  1158.36

Aromaticity  0

Average rotatable bonds  3.10714285714286

Number of hydrogen bond donors  41

Number of hydrogen bond acceptors  37

X logP energy  -13.61439

Hydropathy 



Literature Information


Title  Influence of charge variation in the Streptomyces venezuelae alpha-amylase signal peptide on heterologous protein production by Streptomyces lividans

DOI  10.1007/s002530051193,

Publication Year  1998

PubMed ID  9615485,

Patent ID  NA,



Faculty of Applied Sciences, Macao Polytechnic University, Macao, China.