SPKB

Signal Peptide Knowledge Base

General Information


SPKB ID  SPKB00390

Signal sequence   MLLLVTSLLLCELPHPAFLLI

Length  21

Organism  Artificial

UniProt ID  NA,

Motif  1..21



Activity Information


Pathway  SRP-dependent

Natural/Artificial  Artificial

Subcellular location  ER

Secretion efficiency  BCMA protein detection signal-to-background ratio: 52.80

Type  Sec/SPI



Structure Information


PDB ID  NA,

Predicted Structure ID  SPKB00390.cif

Structure  SPKB00390.cif
Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)
Loading PAE…
Expected Position Error (Ångströms)


Physicochemical Information


Molecular weight  2350.00194

Aliphatic index  204.2857143

Isoelectric point  5.36107726

Charge (pH=7)   -0.971306203

Topological polar surface area  734.18

Aromaticity  0.047619048

Average rotatable bonds  3.476190476

Number of hydrogen bond donors  25

Number of hydrogen bond acceptors  28

X logP energy  1.3729

Hydropathy 



Literature Information


Title  Signal peptide for improving BCMA protein expression efficiency and application thereof

DOI  NA,

Publication Year  2024

PubMed ID  NA,

Patent ID  CN118255844A,



Faculty of Applied Sciences, Macao Polytechnic University, Macao, China.