SPKB

Signal Peptide Knowledge Base

General Information


SPKB ID  SPKB00384

Signal sequence   MKLPVRLLVLMFWIPAASA

Length  19

Organism  Artificial

UniProt ID  NA,

Motif  1..19



Activity Information


Pathway  NA

Natural/Artificial  Artificial

Subcellular location  Periplasmic space

Secretion efficiency  Anti-cTnI antibodies production: 400 to 450mg/L

Type  NA



Structure Information


PDB ID  NA,

Predicted Structure ID  SPKB00384.cif

Structure  SPKB00384.cif
Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)
Loading PAE…
Expected Position Error (Ångströms)


Physicochemical Information


Molecular weight  2156.76204

Aliphatic index  148.9473684

Isoelectric point  11.65177567

Charge (pH=7)   1.997685954

Topological polar surface area  693.48

Aromaticity  0.105263158

Average rotatable bonds  3.473684211

Number of hydrogen bond donors  24

Number of hydrogen bond acceptors  25

X logP energy  0.59677

Hydropathy 



Literature Information


Title  Signal peptide for improving yield of recombinant antibody and application thereof

DOI  NA,

Publication Year  2024

PubMed ID  NA,

Patent ID  CN118063556A,



Faculty of Applied Sciences, Macao Polytechnic University, Macao, China.