SPKB

Signal Peptide Knowledge Base

General Information


SPKB ID  SPKB00381

Signal sequence   MESPSAPPHRWCIPWQRLLLTASLLTFWNPPTTA

Length  34

Organism  Artificial

UniProt ID  NA,

Motif  1..34



Activity Information


Pathway  SRP-dependent

Natural/Artificial  Artificial

Subcellular location  ER

Secretion efficiency  NA

Type  Sec/SPI



Structure Information


PDB ID  NA,

Predicted Structure ID  SPKB00381.cif

Structure  SPKB00381.cif
Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)
Loading PAE…
Expected Position Error (Ångströms)


Physicochemical Information


Molecular weight  3919.57694

Aliphatic index  77.64705882

Isoelectric point  8.55741055

Charge (pH=7)   1.028687175

Topological polar surface area  1435.82

Aromaticity  0.117647059

Average rotatable bonds  3.235294118

Number of hydrogen bond donors  50

Number of hydrogen bond acceptors  50

X logP energy  -10.13406

Hydropathy 



Literature Information


Title  Tumor vaccine signal peptide for enhancing HLA class I molecular antigen presentation and application thereof

DOI  NA,

Publication Year  2024

PubMed ID  NA,

Patent ID  CN117756917A,



Faculty of Applied Sciences, Macao Polytechnic University, Macao, China.