SPKB

Signal Peptide Knowledge Base

General Information


SPKB ID  SPKB00380

Signal sequence   MLLSVPLLLGLLGLAVA

Length  17

Organism  Artificial

UniProt ID  NA,

Motif  1..17



Activity Information


Pathway  SRP-dependent

Natural/Artificial  Artificial

Subcellular location  ER

Secretion efficiency  The production of anti-cTnI antibodies has reached 400-450mg/L

Type  Sec/SPI



Structure Information


PDB ID  NA,

Predicted Structure ID  SPKB00380.cif

Structure  SPKB00380.cif
Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)
Loading PAE…
Expected Position Error (Ångströms)


Physicochemical Information


Molecular weight  1693.20454

Aliphatic index  229.4117647

Isoelectric point  6.099999998

Charge (pH=7)   -0.002015701

Topological polar surface area  540.36

Aromaticity  0

Average rotatable bonds  3.176470588

Number of hydrogen bond donors  18

Number of hydrogen bond acceptors  20

X logP energy  0.3901

Hydropathy 



Literature Information


Title  Tumor vaccine signal peptide for enhancing HLA class I molecular antigen presentation and application thereof

DOI  NA,

Publication Year  2024

PubMed ID  NA,

Patent ID  CN117756917A,



Faculty of Applied Sciences, Macao Polytechnic University, Macao, China.