SPKB

Signal Peptide Knowledge Base

General Information


SPKB ID  SPKB00363

Signal sequence   MKQQKRLYARLLTLLFALIFLLPHSAA

Length  27

Organism  Artificial

UniProt ID  NA,

Motif  1..27



Activity Information


Pathway  Sec

Natural/Artificial  Artificial

Subcellular location  Extracellular environment

Secretion efficiency  Increase Disp43 production by 2.4 times

Type  Sec/SPI



Structure Information


PDB ID  NA,

Predicted Structure ID  SPKB00363.cif

Structure  SPKB00363.cif
Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)
Loading PAE…
Expected Position Error (Ångströms)


Physicochemical Information


Molecular weight  3156.91254

Aliphatic index  144.8148148

Isoelectric point  11.67668797

Charge (pH=7)   4.087446286

Topological polar surface area  1162.52

Aromaticity  0.111111111

Average rotatable bonds  3.888888889

Number of hydrogen bond donors  41

Number of hydrogen bond acceptors  39

X logP energy  -4.15496

Hydropathy 



Literature Information


Title  Dispersed proteins expressed with amylase signal peptides

DOI  NA,

Publication Year  2023

PubMed ID  NA,

Patent ID  CN116529384A,



Faculty of Applied Sciences, Macao Polytechnic University, Macao, China.