SPKB

Signal Peptide Knowledge Base

General Information


SPKB ID  SPKB00325

Signal sequence   MSVPTQVLGLLLLWLTDSRT

Length  20

Organism  Artificial

UniProt ID  NA,

Motif  1..20



Activity Information


Pathway  SRP-dependent

Natural/Artificial  Artificial

Subcellular location  ER

Secretion efficiency  Terminal extension ratio less than 3%

Type  Sec/SPI



Structure Information


PDB ID  NA,

Predicted Structure ID  SPKB00325.cif

Structure  SPKB00325.cif
Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)
Loading PAE…
Expected Position Error (Ångströms)


Physicochemical Information


Molecular weight  2243.68974

Aliphatic index  146

Isoelectric point  6.338718596

Charge (pH=7)   -0.001572528

Topological polar surface area  866.66

Aromaticity  0.05

Average rotatable bonds  3.55

Number of hydrogen bond donors  31

Number of hydrogen bond acceptors  30

X logP energy  -6.05673

Hydropathy 



Literature Information


Title  Signal peptides for reducing terminal heterogeneity of heterologous polypeptides

DOI  NA,

Publication Year  2023

PubMed ID  NA,

Patent ID  CN116234814A,



Faculty of Applied Sciences, Macao Polytechnic University, Macao, China.