SPKB

Signal Peptide Knowledge Base

General Information


SPKB ID  SPKB00318

Signal sequence   MSVPTQVLGLLLLWLTDARS

Length  20

Organism  Artificial

UniProt ID  NA,

Motif  1..20



Activity Information


Pathway  SRP-dependent

Natural/Artificial  Artificial

Subcellular location  ER

Secretion efficiency  Terminal extension ratio less than 3%

Type  Sec/SPI



Structure Information


PDB ID  8TCO,

Predicted Structure ID  SPKB00318.cif

Structure  SPKB00318.cif
Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)
Loading PAE…
Expected Position Error (Ångströms)


Physicochemical Information


Molecular weight  2213.66344

Aliphatic index  151

Isoelectric point  6.338718596

Charge (pH=7)   -0.001572528

Topological polar surface area  846.43

Aromaticity  0.05

Average rotatable bonds  3.5

Number of hydrogen bond donors  30

Number of hydrogen bond acceptors  29

X logP energy  -5.41763

Hydropathy 



Literature Information


Title  Signal peptides for reducing terminal heterogeneity of heterologous polypeptides

DOI  NA,

Publication Year  2023

PubMed ID  NA,

Patent ID  CN116234814A,



Faculty of Applied Sciences, Macao Polytechnic University, Macao, China.