SPKB

Signal Peptide Knowledge Base

General Information


SPKB ID  SPKB00316

Signal sequence   MSVPTQVLGLLLLWLTDARA

Length  20

Organism  Artificial

UniProt ID  NA,

Motif  1..20



Activity Information


Pathway  SRP-dependent

Natural/Artificial  Artificial

Subcellular location  ER

Secretion efficiency  Terminal extension ratio less than 3%

Type  Sec/SPI



Structure Information


PDB ID  8TCO,

Predicted Structure ID  SPKB00316.cif

Structure  SPKB00316.cif
Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)
Loading PAE…
Expected Position Error (Ångströms)


Physicochemical Information


Molecular weight  2197.66404

Aliphatic index  156

Isoelectric point  6.338718596

Charge (pH=7)   -0.001572528

Topological polar surface area  826.2

Aromaticity  0.05

Average rotatable bonds  3.45

Number of hydrogen bond donors  29

Number of hydrogen bond acceptors  28

X logP energy  -4.39003

Hydropathy 



Literature Information


Title  Signal peptides for reducing terminal heterogeneity of heterologous polypeptides

DOI  NA,

Publication Year  2023

PubMed ID  NA,

Patent ID  CN116234814A,



Faculty of Applied Sciences, Macao Polytechnic University, Macao, China.