SPKB

Signal Peptide Knowledge Base

General Information


SPKB ID  SPKB00295

Signal sequence   MEWSWVFLFFLSLTGCHC

Length  18

Organism  Artificial

UniProt ID  NA,

Motif  1..18



Activity Information


Pathway  SRP-dependent

Natural/Artificial  Artificial

Subcellular location  ER

Secretion efficiency  Terminal extension ratio less than 3%

Type  Sec/SPI



Structure Information


PDB ID  NA,

Predicted Structure ID  SPKB00295.cif

Structure  SPKB00295.cif
Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)
Loading PAE…
Expected Position Error (Ångströms)


Physicochemical Information


Molecular weight  2206.62244

Aliphatic index  81.11111111

Isoelectric point  5.358674626

Charge (pH=7)   -1.033280919

Topological polar surface area  716.27

Aromaticity  0.277777778

Average rotatable bonds  3.611111111

Number of hydrogen bond donors  28

Number of hydrogen bond acceptors  27

X logP energy  -0.9496

Hydropathy 



Literature Information


Title  Signal peptides for reducing terminal heterogeneity of heterologous polypeptides

DOI  NA,

Publication Year  2023

PubMed ID  NA,

Patent ID  CN116234814A,



Faculty of Applied Sciences, Macao Polytechnic University, Macao, China.