SPKB

Signal Peptide Knowledge Base

General Information


SPKB ID  SPKB00269

Signal sequence   MEWSWVFLFFLSLTGAHG

Length  18

Organism  Artificial

UniProt ID  NA,

Motif  1..18



Activity Information


Pathway  SRP-dependent

Natural/Artificial  Artificial

Subcellular location  ER

Secretion efficiency  Terminal extension ratio less than 3%

Type  Sec/SPI



Structure Information


PDB ID  NA,

Predicted Structure ID  SPKB00269.cif

Structure  SPKB00269.cif
Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)
Loading PAE…
Expected Position Error (Ångströms)


Physicochemical Information


Molecular weight  2128.47554

Aliphatic index  86.66666667

Isoelectric point  5.363507222

Charge (pH=7)   -0.909331487

Topological polar surface area  716.27

Aromaticity  0.277777778

Average rotatable bonds  3.5

Number of hydrogen bond donors  26

Number of hydrogen bond acceptors  25

X logP energy  -1.1579

Hydropathy 



Literature Information


Title  Signal peptides for reducing terminal heterogeneity of heterologous polypeptides

DOI  NA,

Publication Year  2023

PubMed ID  NA,

Patent ID  CN116234814A,



Faculty of Applied Sciences, Macao Polytechnic University, Macao, China.