SPKB

Signal Peptide Knowledge Base

General Information


SPKB ID  SPKB00260

Signal sequence   MKTKTLLLWVLLLWVPGSTG

Length  20

Organism  Artificial

UniProt ID  NA,

Motif  1..20



Activity Information


Pathway  SRP-dependent

Natural/Artificial  Artificial

Subcellular location  ER

Secretion efficiency  Nuclear membrane protein TMEM176B: 247mg/L

Type  Sec/SPI



Structure Information


PDB ID  NA,

Predicted Structure ID  SPKB00260.cif

Structure  SPKB00260.cif
Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)
Loading PAE…
Expected Position Error (Ångströms)


Physicochemical Information


Molecular weight  2256.81804

Aliphatic index  146

Isoelectric point  10.80537956

Charge (pH=7)   1.997394232

Topological polar surface area  771.97

Aromaticity  0.1

Average rotatable bonds  3.55

Number of hydrogen bond donors  28

Number of hydrogen bond acceptors  28

X logP energy  -1.4391

Hydropathy 



Literature Information


Title  Mutant signal peptide, recombinant vector containing mutant signal peptide and application of mutant signal peptide

DOI  NA,

Publication Year  2023

PubMed ID  NA,

Patent ID  CN116082456A,



Faculty of Applied Sciences, Macao Polytechnic University, Macao, China.