SPKB

Signal Peptide Knowledge Base

General Information


SPKB ID  SPKB00244

Signal sequence   MDWTWRVFFWLLAVAPGAHP

Length  20

Organism  Artificial

UniProt ID  NA,

Motif  1..20



Activity Information


Pathway  SRP-dependent

Natural/Artificial  Artificial

Subcellular location  ER

Secretion efficiency  GLP-1-Fc fusion protein: 3.1g/L

Type  Sec/SPI



Structure Information


PDB ID  NA,

Predicted Structure ID  SPKB00244.cif

Structure  SPKB00244.cif
Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)
Loading PAE…
Expected Position Error (Ångströms)


Physicochemical Information


Molecular weight  2400.82864

Aliphatic index  83

Isoelectric point  7.550936504

Charge (pH=7)   0.089336563

Topological polar surface area  794.12

Aromaticity  0.25

Average rotatable bonds  3.25

Number of hydrogen bond donors  28

Number of hydrogen bond acceptors  26

X logP energy  0.21227

Hydropathy 



Literature Information


Title  Application of signal peptide in expression of GLP-1 fusion protein

DOI  NA,

Publication Year  2022

PubMed ID  NA,

Patent ID  CN114539357A,



Faculty of Applied Sciences, Macao Polytechnic University, Macao, China.