SPKB

Signal Peptide Knowledge Base

General Information


SPKB ID  SPKB00241

Signal sequence   MDWTWRVFCLLAVAPGVHP

Length  19

Organism  Artificial

UniProt ID  NA,

Motif  1..19



Activity Information


Pathway  SRP-dependent

Natural/Artificial  Artificial

Subcellular location  ER

Secretion efficiency  GLP-1-Fc fusion protein: 3.3g/L

Type  Sec/SPI



Structure Information


PDB ID  NA,

Predicted Structure ID  SPKB00241.cif

Structure  SPKB00241.cif
Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)
Loading PAE…
Expected Position Error (Ångströms)


Physicochemical Information


Molecular weight  2198.63144

Aliphatic index  97.36842105

Isoelectric point  7.359696704

Charge (pH=7)   0.027361847

Topological polar surface area  749.23

Aromaticity  0.157894737

Average rotatable bonds  3.210526316

Number of hydrogen bond donors  27

Number of hydrogen bond acceptors  26

X logP energy  -1.67333

Hydropathy 



Literature Information


Title  Application of signal peptide in expression of GLP-1 fusion protein

DOI  NA,

Publication Year  2022

PubMed ID  NA,

Patent ID  CN114539357A,



Faculty of Applied Sciences, Macao Polytechnic University, Macao, China.