SPKB

Signal Peptide Knowledge Base

General Information


SPKB ID  SPKB00178

Signal sequence   MKKAFILSAAAAVGLFTFGGVQQADA

Length  26

Organism  Artificial

UniProt ID  NA,

Motif  1..26



Activity Information


Pathway  NA

Natural/Artificial  Artificial

Subcellular location  Extracellular environment

Secretion efficiency  Alkaline protease activity: 0.4U/mL

Type  NA



Structure Information


PDB ID  NA,

Predicted Structure ID  SPKB00178.cif

Structure  SPKB00178.cif
Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)
Loading PAE…
Expected Position Error (Ångströms)


Physicochemical Information


Molecular weight  2613.06984

Aliphatic index  94.23076923

Isoelectric point  9.537297863

Charge (pH=7)   0.997840716

Topological polar surface area  1006.8

Aromaticity  0.115384615

Average rotatable bonds  3.307692308

Number of hydrogen bond donors  34

Number of hydrogen bond acceptors  35

X logP energy  -8.8799

Hydropathy 



Literature Information


Title  Signal peptide mutant for increasing secretion volume of heterologous protein and construction method and application of signal peptide mutant

DOI  NA,

Publication Year  2020

PubMed ID  NA,

Patent ID  CN111205354A,



Faculty of Applied Sciences, Macao Polytechnic University, Macao, China.