SPKB

Signal Peptide Knowledge Base

General Information


SPKB ID  SPKB00177

Signal sequence   MKKIWIGMLAAAVLLLMVPKVSLADA

Length  26

Organism  Artificial

UniProt ID  NA,

Motif  1..26



Activity Information


Pathway  NA

Natural/Artificial  Artificial

Subcellular location  Extracellular environment

Secretion efficiency  Alkaline protease activity: 0.29U/mL

Type  NA



Structure Information


PDB ID  NA,

Predicted Structure ID  SPKB00177.cif

Structure  SPKB00177.cif
Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)
Loading PAE…
Expected Position Error (Ångströms)


Physicochemical Information


Molecular weight  2783.57154

Aliphatic index  157.6923077

Isoelectric point  10.50691891

Charge (pH=7)   1.997545682

Topological polar surface area  933.41

Aromaticity  0.038461538

Average rotatable bonds  3.576923077

Number of hydrogen bond donors  32

Number of hydrogen bond acceptors  35

X logP energy  -1.1166

Hydropathy 



Literature Information


Title  Signal peptide mutant for increasing secretion volume of heterologous protein and construction method and application of signal peptide mutant

DOI  NA,

Publication Year  2020

PubMed ID  NA,

Patent ID  CN111205354A,



Faculty of Applied Sciences, Macao Polytechnic University, Macao, China.