SPKB

Signal Peptide Knowledge Base

General Information


SPKB ID  SPKB00176

Signal sequence   MKNMSCKLVVSVTLFFSFLTIGPLAHA

Length  27

Organism  Artificial

UniProt ID  NA,

Motif  1..27



Activity Information


Pathway  NA

Natural/Artificial  Artificial

Subcellular location  Extracellular environment

Secretion efficiency  Alkaline protease activity: 24.4U/mL

Type  NA



Structure Information


PDB ID  NA,

Predicted Structure ID  SPKB00176.cif

Structure  SPKB00176.cif
Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)
Loading PAE…
Expected Position Error (Ångströms)


Physicochemical Information


Molecular weight  2955.62794

Aliphatic index  111.8518519

Isoelectric point  9.677346754

Charge (pH=7)   2.026328607

Topological polar surface area  1036.09

Aromaticity  0.111111111

Average rotatable bonds  3.518518519

Number of hydrogen bond donors  37

Number of hydrogen bond acceptors  40

X logP energy  -6.6192

Hydropathy 



Literature Information


Title  Signal peptide mutant for increasing secretion volume of heterologous protein and construction method and application of signal peptide mutant

DOI  NA,

Publication Year  2020

PubMed ID  NA,

Patent ID  CN111205354A,



Faculty of Applied Sciences, Macao Polytechnic University, Macao, China.